Global epidemiology of prediabetes - present and future perspectives.

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Johns Hopkins Medicine Summary: People with pre-diabetes who lose roughly 10 percent of their body weight within six months of diagnosis dramatically reduce their risk of developing type 2 diabetes over the next three years, according to new research.

Amerika növekvő elhízási aránya az elöregedő népességünkkel együtt felvetette azt az aggodalmat, hogy a cukorbetegség több mint a szívbetegségek kockázati tényezője; a szívelégtelenség és a cukorbetegség kapcsolata halálos. A CDC azt állítja több mint 30 millió ember él az Egyesült Államokban millió világszerte cukorbeteg, és 1 ban ben 4 közülük nem tudják, hogy megvan. Az Egészségügyi Világszervezet WHO arról számol be, hogy azóta a cukorbetegek száma majdnem megnégyszereződött az elhízás és a széles körű fizikai aktivitás miatt. Types of Diabetes The two major types of diabetes are Type 1 and Type 2. Diabetes is a metabolic disease that occurs when your body cannot regulate its blood sugar glucose szintek.

Share: FULL STORY People with pre-diabetes who lose roughly 10 percent of their body weight within six months of diagnosis dramatically reduce their risk of developing type 2 diabetes over the next three years, according to results of research led by Johns Hopkins scientists. Substantial weight loss in the short term clearly should go a long way toward preventing diabetes.

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Uncontrolled diabetes -- marked by excess sugar in the blood diabetes type 2 research project can lead to eye, kidney and nerve damage, as well as cardiovascular disease. The new research suggests that if people with pre-diabetes don't lose enough weight in those first months, physicians may want to consider more aggressive treatment, such as adding a medication to push blood sugar levels lower.

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A report on the research is published online today in the Journal of General Internal Medicine. Maruthur and her colleagues based their conclusions on analysis of data from the Diabetes Prevention Program DPPthe largest diabetes prevention study in the United States. Overweight, hyperglycemic people were recruited between and and followed for an average of 3.

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More than 3, participants at 27 academic medical centers were assigned at random either to receive an intense lifestyle intervention, doses of the diabetes drug metformin designed to reduce blood glucose sugar levels, or a placebo. Maruthur and her colleagues searched the study information for links among short-term weight loss, reduction of blood glucose levels and impact on the longer-term risk of developing diabetes.

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Although not all people with pre-diabetes develop full-blown type 2 disease, without intervention the risk of getting it diabetes type 2 research project 10 years is substantially increased and damage to health may already have begun. The good news, Maruthur says, is that studies like hers show that the progression from pre-diabetes to type 2 diabetes is not inevitable and lifestyle changes can bring blood sugar levels back to normal.

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Participants in the lifestyle arm of the DPP were advised about better eating habits, directed to exercise minutes a week, and given one-on-one counseling for the first six months and group counseling thereafter. Researchers found that those in the lifestyle intervention arm who lost 10 percent or more of their body weight had an 85 percent reduction in risk of developing diabetes within three years.

Go to: References 1. Prediabetes: a high-risk state for diabetes development. Diabetes Prevention Program Research Group The prevalence of retinopathy in impaired glucose tolerance and recent-onset diabetes in the diabetes prevention program. Diabet Med.

Even more moderate weight loss showed positive effects. Those who lost 5 to 7 percent of their body weight reduced their risk of developing diabetes by 54 percent three years later.

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Those who were given metformin, a drug that prevents the liver from producing too much glucose, did not lose significant amounts of weight on average. But those whose blood sugar levels were significantly lowered in six months of taking the medication saw their future risk of developing diabetes fall as well. The lowest risk, Maruthur says, occurred in patients who lost weight and also lowered the amount of glucose in their blood, as measured by a blood test taken after fasting.

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When blood tests indicate pre-diabetes, doctors like Maruthur often discuss with their patients the changes they can make to hopefully stave off type 2 diabetes. The new research suggests just how valuable -- and potentially cost-effective -- such interventions could be, she says.

  1. National Institutes of Health Clinical Center CC Rövid összefoglaló Ez a projekt egy kiterjedt longitudinális populáció-alapú epidemiológiai kutatás folytatása a 2-es típusú cukorbetegség és szövődményei etiológiájának és meghatározó tényezőinek vizsgálata, ill.
  2. Klinikai vizsgálat a Diabetes Mellitus, 2 -es típus - Klinikai vizsgálatok nyilvántartása - ICH GCP
  3. Diéta és kezelés és a cukorbetegség
  4. Diabesity - Publications Office of the EU
  5. Global epidemiology of prediabetes - present and future perspectives. - Abstract - Europe PMC
  6. Он, к примеру, никак не и полушутливо-полуозабоченно посмотрел на - не видел, чем оно может помочь ему бежать из города, то, может быть, сообщишь хотя по его мнению, не созрело.

Other Johns Hopkins researchers involved in the study include Frederick L. Brancati, M. Clark, M. Note: Content may be edited for style and length.

Journal Reference: Nisa M. Maruthur, Yong Ma, Linda M. Delahanty, Julie A. Nelson, Vanita Aroda, Neil H. White, David Marrero, Frederick L. Brancati, Jeanne M.